OMEPRAZOLE SODIUM

OMEPRAZOLE SODIUM - Names and Identifiers

Name	sodium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]benzoimidazole
Synonyms	OMEPRAZOLE SODIUM Omeprazole, sodium salt odiuM 5-Methoxy-2-[(4-Methoxy-3,5-diMethyl-pyridin-2-yl)Methylsulfinyl]benzoiMidazole sodium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]benzoimidazole 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole sodium salt
CAS	95510-70-6
EINECS	623-285-9
InChI	InChI=1/C17H18N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H,9H2,1-4H3;/q-1;+1

OMEPRAZOLE SODIUM - Physico-chemical Properties

Molecular Formula	C17H20N3NaO3S
Molar Mass	369.41
Melting Point	>165°C (dec.)
Solubility	Freely soluble in water and in ethanol (96 per cent), soluble in propylene glycol, very slightly soluble in methylene chloride.
Appearance	Solid
Color	White to Off-White
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Stability	Hygroscopic
In vitro study	Omeprazole (H 16868) is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger-Ellison syndrome. Omeprazole (H 16868) virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001). This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1 g daily or ranitidine 300 mg daily. The pharmacokinetics of omeprazole were studied in a group of healthy male subjects after single and repeated oral doses of 30 and 60 mg. Absorption of Omeprazole (H 16868) from its enteric-coated formulation was unpredictable. There was a highly significant increase in the area under the plasma concentration time curve (AUC) after repeated dosing. Omeprazole (H 16868) increases its own relative availability following repeated dosing. This may be due to inhibition of gastric acid secretion by omeprazole which is an acid-labile compound. Omeprazole sodium is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).

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View History

OMEPRAZOLE SODIUM
BIOTIN PURE EP GRADE
Lithium sulphate
ZINC CARBONATE BASIC
NICLOFOLAN
BUPIVACAINE HYDROCHLORIDE
Prednisolone phosphate sodium
CS-1599
Ethyl Thioether
瑞加德松REGADENOSON